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A serial murderer is on the loose, and Holmes and Watson have been on the case. In typical fashion however, Holmes was struck with a breakthrough deduction and ran off. Thinking Holmes had simply solved the case and gone back home, Watson followed shortly behind. But when he arrived at 221B, there was no trace of Holmes - only a note left on the desk, written in the same strange code the killer has been leaving at the scenes of the crimes. Unable to solve the case himself, Watson recruits a top team of forensic investigators to assemble at 221B Baker St, solve the case before time runs out and save Sherlock from the sadistic killer.